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Wednesday, July 15, 2020 | History

2 edition of Identification of novel anticancer compounds from primates-consumed plant found in the catalog.

Identification of novel anticancer compounds from primates-consumed plant

Anas Subarnas

Identification of novel anticancer compounds from primates-consumed plant

final report

by Anas Subarnas

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  • 22 Currently reading

Published by Kementerian Pendidikan Nasional, Unversitas Padjadjaran, Fakultas Farmasi in Jakarta] .
Written in English


Edition Notes

StatementAnas Subarnas
Classifications
LC ClassificationsMicrofiche 2011/50293 (Q)
The Physical Object
FormatMicroform
Paginationvi, 28, 17 leaves
Number of Pages28
ID Numbers
Open LibraryOL25152414M
LC Control Number2011337595

Plant sources of anti-cancer agents are plants, recently been argued that "the use of natural products has been the single most successful strategy in the discovery of novel medicines". Plants need to defend themselves from attack by micro-organisms, in particular fungi, and they do this by producing anti-fungal chemicals that are toxic to. Title:Novel Anticancer compounds from Endophytic fungi VOLUME: 7 ISSUE: 3 Author(s):Ashish Bedi, Alok Adholeya and Sunil Kumar Deshmukh* Affiliation:TERI-Deakin Nano Biotechnology Centre, The Energy and Resources Institute (TERI), Darbari Seth Block, IHC complex, Lodhi Road, New Delhi – , TERI-Deakin Nano Biotechnology Centre, The Energy and Resources Institute (TERI), .

Anticancer plants: Volume 1, Properties and Application is a very timely effort in this direction. Discussing the various types of anticancer plants as a source of curative agent, their pharmacological and neutraceutical properties, cryo-preservations and recent trends to understand the basic cause and consequences involved in the diseases. Naturally occurring anticancer compounds represent about half of the chemotherapeutic drugs which have been put in the market against cancer until date. Computer-based or in silico virtual screening methods are often used in lead/hit discovery protocols. In this study, the “drug-likeness” of ∼ compounds from African medicinal plants that have shown in vitro and/or in vivo anticancer.

Obtaining anticancer compounds from orchids should help reduce the unpleasant side effects associated with current cancer treatment methods as natural and . Of the above 62 compounds, 12 have good separation in the positive ion mode, and 27 compounds have good separation in the anion mode. Currently, 39 have been reported in the literature related to the chemical composition of the plant, while the other 23 of the 62 compounds have not been reported.


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Identification of novel anticancer compounds from primates-consumed plant by Anas Subarnas Download PDF EPUB FB2

An additional argument associated with the nanoparticles is the limitation of multi-drug resistance. Although several compounds of plant origin are known to serve as anticancer drugs, modern medicine lacks effective drugs against certain types of cancers, for example, metastatic pancreatic adenocarcinoma and castration-resistant prostate by:   Fig.

1 Plant derived anticancer agents in clinical application Plant-derived anticancer agents in clinical develop- ment The flavone, flavopiridol is totally synthetic, but the ba- sis for its novel structure is a natural product, rohitukine, isolated by chemists at Hoechst India Ltd.

in the early s from Dysoxylum binectariferum Hook. f Cited by:   d. Anticancer plant-derived drugs. Plant-derived drugs are desired for anticancer treatment as they are natural and readily available. They can be readily administered orally as part of patient’s dietary intake Also, being naturally derived compounds from plants they are generally more tolerated and non-toxic to normal human cells Cited by:   Anticancer compounds from algae.

More than 50% of the marine blue-green algae are largely used for the isolation of anticancer compounds which are effective in either inducing apoptosis or triggering signaling pathways through activation of protein kinase-c enzymes, NF-κB, MAPK kinases, p53, cytokines release and ROS by: Anticancer Plants: Natural Products and Biotechnological Implements – Volume 2” explores the natural bioactive compounds isolated from plants as well as fungal endophytes, their chemistry, and preventive effects to reduce the risk of cancer.

Moreover, it highlights the genomics/proteomics approaches and biotechnological implementations. Alternatively, plant cell tissue and organ culture biotechnology can be adopted to produce these anticancer compounds without cultivation. The proper knowledge and exploration of these isolated molecules or products could provide an alternative source to reduce cancer risk, anti-tumorigenic properties, and suppression of carcinogen activities.

Several more recently isolated compounds obtained from plants showing promising in vivo biological activity are also discussed in terms of their potential as anticancer agents, with many of these obtained from species that grow in tropical regions. Since extracts of only a relatively small proportion of the ca.

higher plants on earth. Natural compounds have been the critical sources of anti-cancer drug research and discovery for decades (Cragg, Grothaus, & Newman, ). A panel of well-known anti-cancer drugs such as camptothecin, paclitaxel, and vinblastine, are directly derived from natural plants and herbs.

Inwe published a review of cytotoxic or anticancer compounds produced by plant endophytes. Over compounds with demonstrated cytotoxicity or anticancer activity had been isolated from endophytic fungi—including several compounds originally isolated from higher plants [ 8 ].

Plants consumed by non-human primates represent potential drug sources for human disease management. In this study, we isolated kaempferolO-rhamnoside as an active compound from the leaves of Schima wallichiiKorth., a plant commonly consumed by non-human primates.

Essential oils from certain plants that are mixtures of several bioactive compounds can be the basis for the identification of novel anticancer molecules that can further be exploited in. Phenolic compounds, as an important class of natural products, are the main bioactive constituents in many dietary and medicinal plants.

They have been reported to show extensive benefits to human health, including antioxidant, antiinflammatory, and anticancer activities. Despite presence of voluminous biomedical literature in PubMed that provides evidence for variety of naturally occurring compounds demonstrating anti-neoplastic activity, to our knowledge, no resource exists that focuses on plant-based naturally occurring compounds with anti-cancerous activity, although a few natural compound databases like.

There are concerns about using synthetic phenolic antioxidants such as butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA) as food additives because of the reported negative effects on human health.

Thus, a replacement of these synthetics by antioxidant extractions from various foods has been proposed. More than different phenolic compounds have been characterized; fruits. This book summarizes the application of plant derived anticancer compounds as chemopreventives to treat several cancer types, focusing on the molecular mechanisms of action of phytocompounds and providing an overview of the basic processes at the cellular and molecular level that are involved in the progression of the cancer and can be employed in targeted preventive therapies.

The traditional Chinese medicinal plants associated with anticancer in this study were selected and collected from those listed in the four references Zhang and Gong,Ji et al.,Xu et al.,Bo et al., In total, species in 50 plant families from various locations in China were purchased and collected with – g per sample, from a well-known trade market for.

[1,2] These selected medicinal plants show the anticancer, antioxidant property. [3] This can be further used for the treatment of tumor, oxidative stress.

Phytoconstituents derived from the herbs of Cedrus Deodara, Piper Longum, Picrorhiza kurroa, Berberis Aristata, Vitex Negundo linn, etc. have been used in. Homoharringtonine.

Other plant-derived agents,which are in clinical use, are homoharringtonine. Homoharringtonine was originally isolated from the Chinese tree Cephalotaxus harringtonia var.

drupacea (Cephalotaxaceae).Elliptinium was isolated from species of several genera of the Apocynaceae familyincluding Bleekeria vitensis, a Fijian medicinal plant with reputed anti-cancer properties.

Anticancer Activity of Natural Compounds from Plant and Marine Environment Article (PDF Available) in International Journal of Molecular Sciences 19(11) November with 2, Reads. presents known anticancer drugs that have been approved for use, as well as new analogies and other less known substances with anti-cancer properties that may be considered as potential chemotherapy drugs.

The uses, mechanisms of action, and doses of natural compounds from plants and the marine environment are presented in Tables1and2. This compound was obtained through a phenotypic-based screening of more t microbial extracts from Medina’s NP Library following a cytotoxicity screening in 2D cancer cell culture and a dereplication and identification of the novel compound.

Promising results with this novel compound have been obtained from an in vivo mice model of.We observed that the L. acaciae n-hexane extract (LAHE) could inhibit cancer cell growth, particularly of MCF7 and A cells. Chromatographic purification of LAHE and nuclear magnetic resonance analysis led to the identification of two compounds from this plant species, namely, betulinic acid and β-sitosterol, for the first time.Four compounds were able to inhibit the proliferation of human cancer cells at a concentration of 50 μg mL −1.

Compounds 2 and 3 showed significant anticancer activity against A and HEPG2 cells. Compounds 4 and 5 were effective against A cells.

The present study demonstrates that this bioassay-guided offline two-dimensional preparative.